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A "real illness" can result in the collapse of coping mechanism. It can result in behaviour that makes the condition worse. Those with liver disease may continue to drink or tobacco users with lung damage may just cut down and not give up. Unrecognised depression and anxiety can produce and also aggravate underlying physical illness. Feeling sad and "down" is normal, but it has progressed to depression when symptoms like a feeling of hopelessness, lack of energy, thoughts of suicide, withdrawal from friends, inability to sleep or sleeping too much, difficulty in concentrating and decision-making appear and persist. Eventually, there may no longer be an obvious precipitating factor or reason, and relationships and work may suffer. Anxiety is normal. The body's reaction to danger makes the body secrete the chemicals adrenaline and noradrenaline. They make the heart beat rapidly, quicken defensive actions and shorten response time. It can be regarded as abnormal if it occurs several times a day, is without any discernible reason and interferes with daily activities. A continuous feeling of tension, fast heart rate, rapid breathing, trembling, sweating, difficulty in concentrating and a feeling of nausea and diarrhoea may accompany it. These may be precipitated by illness like heart disease, diabetes, hyperthyroidism and the use of alcohol or recreational drugs.