In population genetics a sexual population is a set of organisms in which any pair of members can breed together. This means that they can regularly exchange gametes to produce normally-fertile offspring, and such a breeding group is also known therefore as a Gamo deme. This also implies that all members belong to the same species.[4] If the Gamo deme is very large (theoretically, approaching infinity), and all gene alleles are uniformly distributed by the gametes within it, the Gamo deme is said to be panmictic. Under this state, allele (gamete) frequencies can be converted to genotype (zygote) frequencies by expanding an appropriate quadratic equation, as shown by Sir Ronald Fisher in his establishment of quantitative genetics.[5] This seldom occurs in nature: localization of gamete exchange – through dispersal limitations, preferential mating, cataclysm, or other cause – may lead to small actual Gamo demes which exchange gametes reasonably uniformly within themselves but are virtually separated from their neighboring Gamo demes. However, there may be low frequencies of exchange with these neighbors. This may be viewed as the breaking up of a large sexual population (panmictic) into smaller overlapping sexual populations. This failure of panmixia leads to two important changes in overall population structure: (1) the component Gamo demos vary (through gamete sampling) in their allele frequencies when compared with each other and with the theoretical panmictic original (this is known as dispersion, and its details can be estimated using expansion of an appropriate binomial equation); and (2) the level of homozygosity rises in the entire collection of Gamo demes.